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A q for our resident research assistant...

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Just wondering about something, I recall a loooooong time ago, and I may be totally mistaken, that there was some reaseach done into either comparative deteriorative effects of alcohol and other drugs whilst driving, or it was something on the relative IQ's of smokers to drinkers... or something to that effect... not very precise eh? How about I just word it as a question...


Have there been any studies into the IQ levels of long term, medium term and short term users of cannabis as compared to those who use no recreational drugs and long term, medium term and short term users of alcohol? I'm interested because of there is a lot of anectodal evidence that cannabis use is not detrimental, but actually good for creative expression and similar mental activities... we all know about the long touted problems with short term memory loss, but what about other mental function? And has cannabis use ever been shown to have a detrimental long term effect on intelligence? I doubt it has, but I'd be interested to read anything you can dig up on the subject in your reasearch files. ;)


If anyone else has an opinion or information regarding this, feel free to post here too, I'm interested in whether you guys think pot is not just making us forget our car keys, but making us morons too... I personally don't think MJ does affect intelligence, but hey, there could be some reasearch out there I'm not aware of yet, and thus this post has been born. B)


I'll look forward to the replies.... lol

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Guest Wilderbud

I dont blame marijuana for my stupidness that became apparent about 5 years ago.


I didnt get a TE score at school so I started a preparation for tertiary studies course which had me doing grade 11/12 in a 1 year course - I was sick of having crap jobs because of my supposed stupidity [left school early becasue it bored me and held me back from learning computers at home]. I was so dumb for a few weeks into the course and didnt remember all the maths which I used to ace for a long time but after a few weeks I was relearning it quickly and I was still smoking although it was only at night and weekends. A few other mature age students noticed they couldnt count money also at the start of the course - heh [didnt worry me too much as people straight out of school were in the same boat].


I think I was stupid because Ive never had a job that required me to think and I didnt do any education at home. I now do a lot of computing like in the old days and I have less trouble with remembering how to work out a math problem these days although I prefer to stay away from advanced maths problems as I do still have trouble remembering things I dont use every day [vector maths and physics for example].


I just mess around on the net and help others with computer problems when Im not high but when I get high I like to learn and try new things with my computer as Ive always wanted a job as a computer guru so I wont stop learning new things now.

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im not sure if its relevent but.....

i read somewhere that "most" of the research in the US done on marijuana is bullshit. Kraft foods are the major sponsor of the anti drug programs and also fund alot of research into mj. Ahhh arent Kraft nice... well no, not really. Kraft is owned by Phillip Morris and in the eyes of cig companies, mj is potential competition.

I dont know if any of its true but if you want ill dig up where i found it. There was alot more than that on there but i forgot the rest lol.


An Australian study l8ly says long term use can increase the chance of becoming skitzo. Thats fine with me. I had a cousin who was skitz, he used to have heaps of fun doing all kinds of crazy shit B)

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Have there been any studies into the IQ levels of long term, medium term and short term users of cannabis as compared to those who use no recreational drugs and long term, medium term and short term users of alcohol?

I don't know of any covering alcohol, but there was a study on IQ levels and cannabis use just last year. Great commentary at http://www.marijuananews.com/news.php3?sid=489

Edited by australian_activist
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lol I wish I was an RA, mate I'm on a disability support pension so I have a lot of time to read, but my ego appreciates the compliment. Yeah no problem I have seen lots of info like this so I will look for something recent that matches your Qs about IQ and driving, ie. comparative studies of Ethol and mj (and any other drugs?). There is a lot on brain disorders like schizophrenia etc. but I will concentrate on memory (s/m/l), don't hesitate to give me a hurry up if you think I am f*cking around or add a few more Q's (as can any member/guest), hopefully it won't take as long as pipemans request and hopefully I will be more helpful to you than I was for pipeman and white cluster.

On a side note I had a look at the SI chem data book and CO2 is a linear molecule so I would have thought the vector addition of these molecule's polarity would cancel each other out but that would make it nonpolar, so hopefully the info about the shape of the molecule will help you answer the q is C02 a bipolar molecule (i think it can only be polar or nonpolar unless it is an ionic interactionie, sorry high school chemistry was about 15 yrs ago so it is pushing the old brain cells a bit. Also I saw some research on THC and extraction and the method used was chloroform I should have posted when I saw it but I 'm sure I will see it again.

Cheers mate and I will probably PM you some additional info tomorrow.

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I don't think Marijuana causes long-term damage, but it depends if pot is the only thing you're using. It's been shown that it can affect the short-term memory with heavy use, but it will regenerate if you give pot a bit of a rest B) And people that are prone to some mental disorders shouldn't use pot, I believe that causes damage.

syk613 Posted on Nov 20 2003, 07:05 PM

  yep, once again I have not Logged In. It is not the 1st time and it won't be the last, peace 

Hey, if you copy and paste it into a new post, i can trash the old one for you, if you'd like lol
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@ chev81

Thanks, if you could remove the other two posts here by me I would be very grateful, thanks again




The 1st ref: and it is the whole paper enjoy, if you want more post /PM me.


© 2002 Canadian Medical Association; Association médicale canadienne



Volume 166(7) 2 April 2002 pp 887-891



Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults


Fried, Peter; Watkinson, Barbara; James, Deborah; Gray, Robert


From the Department of Psychology, Carleton University, Ottawa, Ont.

This article has been peer reviewed.

Contributors: Peter Fried has been the Director of Ottawa Prenatal Prospective Study since its inception. He designed the protocol for the study, as well as the questionnaire that was administered to the subjects. He also made a substantial contribution to the writing and editing of the manuscript. Barbara Watkinson was the primary statistical analyst and made a substantial contribution to the writing and editing of the manuscript. Deborah James assisted in the analyses and made a substantial contribution to the writing and editing of the manuscript. Robert Gray was in charge of data management and extrapolated the data reported in this manuscript. He also assisted in writing the manuscript.

Acknowledgements: This work was supported by a grant to Peter Fried from the National Institute on Drug Abuse, Washington, DC. The authors thank Heather Linttell for her testing of the subjects over the past 15 years and all the families who have participated in the Ottawa Prenatal Prospective Study for the past 2 decades. The urinalysis was carried out under the direction of Dr. Sherry Perkins, Head, Division of Biochemistry, Ottawa Hospital, Ottawa.

Competing interests: None declared.

Correspondence to: Dr. P.A. Fried, Department of Psychology, Carleton University, 1125 Colonel By Drive, Ottawa ON K1S 5B6; fax 613 520-3667; peter_fried@carleton.ca





Table 1






Background: Assessing marijuana's impact on intelligence quotient (IQ) has been hampered by a lack of evaluation of subjects before they begin to use this substance. Using data from a group of young people whom we have been following since birth, we examined IQ scores before, during and after cessation of regular marijuana use to determine any impact of the drug on this measure of cognitive function.


Methods: We determined marijuana use for seventy 17- to 20-year-olds through self-reporting and urinalysis. IQ difference scores were calculated by subtracting each person's IQ score at 9–12 years (before initiation of drug use) from his or her score at 17–20 years. We then compared the difference in IQ scores of current heavy users (at least 5 joints per week), current light users (less than 5 joints per week), former users (who had not smoked regularly for at least 3 months) and non-users (who never smoked more than once per week and no smoking in the past two weeks).


Results: Current marijuana use was significantly correlated (p < 0.05) in a dose- related fashion with a decline in IQ over the ages studied. The comparison of the IQ difference scores showed an average decrease of 4.1 points in current heavy users (p < 0.05) compared to gains in IQ points for light current users (5.8), former users (3.5) and non-users (2.6).


Interpretation: Current marijuana use had a negative effect on global IQ score only in subjects who smoked 5 or more joints per week. A negative effect was not observed among subjects who had previously been heavy users but were no longer using the substance. We conclude that marijuana does not have a long-term negative impact on global intelligence. Whether the absence of a residual marijuana effect would also be evident in more specific cognitive domains such as memory and attention remains to be ascertained.






Marijuana produces well-documented, acute cognitive changes that last for several hours after the drug has been ingested.1,2,3 Whether it produces cognitive dysfunction beyond this period of acute intoxication is much more difficult to establish. Approaches to investigating long-lasting effects include clinical assessment of long-term users,4,5,6 observations of subcultures in countries where long-term daily use of cannabis has been the cultural norm for decades 7,8,9 and marijuana administration studies in which subjects with a history of use ranging from infrequent to extensive are given the drug in controlled laboratory settings after various periods of abstinence.10,11,12 As discussed in several reviews of the literature,1,13,14 the findings have been equivocal.


Most studies that examined heavy marijuana users for possible cognitive dysfunction lasting beyond the acute intoxication period assessed subjects after an abstinence period of only a day or two.10,12,15,16 The fact that cannabinoid metabolites have been detected in the urine of long-term marijuana users after weeks or even months of abstinence 17,18,19 compromises the interpretation of these studies. To account for potential pre-existing differences between users and non-users, studies have typically matched the comparison group with the user group in terms of non-marijuana variables.6,20 Suggestions for improving study designs 13,14 have emphasized both the need for comparison groups to be as similar as possible to the drug-using group and the need for a prolonged abstinence period. The most desirable procedure would involve a longitudinal, prospective design in which cognitive measures were available for all non-using and using subjects before and after marijuana consumption had been initiated by the users.15


The Ottawa Prenatal Prospective Study (OPPS), underway since 1978, satisfies these criteria. This study permits both within-subject and between-subject comparisons among relatively low-risk non-users and users before, during and after quitting regular marijuana use. The primary objective of the OPPS is the neuropsychologic assessment of children exposed prenatally to marijuana or cigarettes. Women who used and did not use marijuana and cigarettes volunteered to participate during their pregnancy, and their children, now between the ages of 17 and 20 years, have been assessed since birth. Details of the recruitment of the largely middle-class families, the assessment procedures and the findings for the children from birth to adolescence have been summarized elsewhere.21,22


The objectives of the current study were as follows: to determine if current, regular marijuana use is predictive of decline in IQ from pre-usage levels, to determine if a differential effect on IQ occurs with heavy versus light current, regular marijuana use, and to determine if any IQ effects persist after subjects cease using marijuana for at least 3 months.



A potential pool of 74 young adults with urinalysis results, self-reports of marijuana use and a broad measure of IQ obtained at both a preteen (9–12 years) and a young adult (17–20 years) assessment was available. Two subjects with inconsistencies between the self- report of marijuana use and the urine screening results were excluded, as were one subject who tested positive for cocaine and another who was taking methylphenidate. Consequently, the final sample comprised 70 subjects whose self-report of marijuana use and absence of hard drug use had been validated by urinalysis results.


During the preteen period and before initiation of marijuana use, IQ was measured by means of the Wechsler Intelligence Scale for Children-III (WISC).23 When the subjects were young adults, IQ was evaluated with the Wechsler Adult Intelligence Scale-III (WAIS).24 The outcome variable for the examination of potential marijuana effects was an IQ difference score, derived by subtracting the preteen WISC IQ score from the young adult WAIS IQ score. Thus a positive difference score reflects an increase in IQ over the approximately 10-year period, whereas a negative score reflects a decrease.


Marijuana use was determined by 2 procedures that were part of an extensive neuropsychologic battery given to the 17– to 20-year-olds. The first consisted of a questionnaire completed by the subject, which asked for details of current and past marijuana use, as well as other drug use. The second was a urine sample analyzed for the presence of cannabinoids, amphetamines, opiates, cocaine and cotinine (a metabolite of nicotine). All metabolite concentrations were adjusted for creatinine to control for urine dilution. Although these procedures did not assess the strength of the marijuana used by the OPPS subjects, an estimate was suggested by Health Canada's analysis of marijuana seized by police between 1996 and 1999, which revealed an average of 5% to 6% tetrahydrocannabinol (THC).


Marijuana measures treated as continuous variables were self-report of mean number of joints currently smoked per week, self-report of length of time (months) that marijuana had been smoked and total estimated number of joints smoked (mean number of joints smoked per week multiplied by number of weeks of use). The mean number of joints currently smoked per week was also treated as a categorical variable, as follows: the subjects were grouped as light current regular users, heavy current regular users, former regular users or non-users.


Categorization of the current marijuana users as light or heavy users was based on both the self-report and the urinalysis data. The urinalysis data were bimodally distributed: 11 subjects had cannabinoid to creatinine ratios between 4 and 54 ng/mg, and 13 subjects had ratios between 147 and 705 ng/mg. These 2 groups of subjects were used to validate the categorization based on self-reports. Defining heavy regular use as at least 5 joints per week (n = 15) and light regular use of any amount less than 5 joints at least once a week (n = 9) optimized concordance with the bimodal urine division as indicated by &b.chi;2 analysis. Eight (73%) of the 11 subjects with the lower metabolite values smoked fewer than 5 joints per week, and 12 (92%) of the 13 subjects with the higher metabolite values smoked an average of 5 or more joints per week (p = 0.001).


Of the 70 subjects, 37 were non-users who had never used marijuana regularly (where regular use was defined as at least once a week) and who had not used any marijuana in the past 2 weeks; 9 were former users who had smoked marijuana regularly in the past but had not smoked for at least 3 months before the young adult assessment; 9 were light current users; and 15 were heavy current users.


The assessments were conducted in laboratories at Carleton University, Ottawa. Given that the testing sessions commenced in the early morning and that all subjects reported no use of marijuana on the day of testing, it is unlikely that the subjects were assessed while in an acute state of intoxication.


The validity of self-reporting for current marijuana use was examined with 2 approaches. The initial selection of the 70 subjects involved a criterion of concordance between self-reports of marijuana use and urine screening results (see above). The second measure of concordance was a high correlation between reported current marijuana use and the cannabinoid to creatinine ratio found with urinalysis (r = 0.70, p < 0.001). Although self-reports of earlier use could not be directly confirmed pharmacologically, their reliability is enhanced by the validity of the self-reporting for current marijuana use.


In examining the relation between marijuana use and IQ difference scores, we considered a variety of potentially confounding variables, including variables related to socioeconomic status, such as family income and parental education; the subject's education level (number of years of education at the time of the young adult assessment); age and sex of the subject; mother's age at the time of the subject's birth; maternal use of cigarettes, marijuana and alcohol during pregnancy; and the subject's use of tobacco and alcohol and exposure to secondhand marijuana smoke. In the subsequent analyses, we controlled for any potential confounding factor that was related to both the marijuana independent variable (at ? = 0.1) and the IQ difference score (at ? = 0.05).25


Hierarchical regression (a statistical approach to measure the impact of marijuana use after considering potential confounders) was used to examine the predictive relation of quantity (both mean number of joints per week and total joints over lifetime) and duration (period of use) of current marijuana use to the IQ difference score. Differential effects on the IQ difference score of light current use, heavy current use and former use as contrasted to non-use were examined with Dunnett's 2-sided multiple comparison procedure 26 with analysis of variance (ANOVA) and analysis of covariance (ANCOVA) when required to control for confounding variables.



Analyses in which number of joints smoked per week was used both as a continuous and as a categorical variable revealed significant associations of this variable with the IQ difference score.


When number of joints smoked per week was treated as a continuous variable, regression analyses revealed a significant negative association with the IQ difference score (r = –0.24, p < 0.05) after accounting for potentially confounding variables. In these analyses, no predictive relation with the IQ difference score was found for the self-reported period of marijuana use or the estimated total number of joints smoked.


For analyses in which number of joints smoked per week was treated as a categorical variable, ANOVA with Dunnett's procedure 26 indicated that the mean IQ difference score for the heavy current user group was significantly different from that for non-users (–4.0 v. 2.6, p < 0.05), whereas no significant differences were evident in comparisons with the light current users and former users (5.8 v. 2.6 and 3.5 v. 2.6 respectively) (Table 1). The characteristics of the 4 groups (light current users, heavy current users, former users and non-users) are presented in Table 1. Of particular importance to the present study is the fact that preteen IQ, assessed before marijuana use, did not differ across the groups. Although some characteristics did differ across the 4 groups (such as father's and mother's education), none of these was associated with the IQ difference score; therefore, they were not used as covariates.




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Table 1. No caption available.




Although there was no overall difference in IQ difference score between former users and non-users, a subgroup of former users, those who had used at least 5 joints per week (heavy use), was analyzed separately; again, there was no significant difference relative to non-users (t-test, p = 0.7). This lack of a negative impact among the former heavy users is striking, as they had smoked, on average, an estimated 5793 joints over 3.2 years (mean of 37 joints per week); in contrast, the current heavy users had smoked, on average, an estimated 2386 joints over 3.1 years (mean of 14 joints per week).



In the present work, the use of commensurable IQ measures obtained before and after initiation of marijuana use permitted examination of the consequences of marijuana use in the context of pre-drug performance. Of all the marijuana and non-marijuana variables considered, only the quantity of current marijuana use, in terms of number of joints smoked per week, was negatively related to change in IQ from preteen to young adult. Not associated with change in IQ were duration of marijuana use, the total quantity of marijuana used and former use of marijuana. In addition, variables such as socioeconomic status (family income and parental education), age of mother at time of subject's birth, subject's prenatal exposure to drugs (nicotine, marijuana and alcohol), preteen IQ score, age, sex, academic history, other drug use and passive marijuana exposure were not predictive of change in IQ score.


The IQ difference score for the heavy current users differed from that for non-users, but no such differences were apparent between light current users and non-users. The clinical significance for an individual of such an effect on IQ scores is difficult to ascertain, but the impact on society might be substantial. IQ scores are considered normally distributed, with a mean of 100 and a standard deviation of 15, and it is therefore estimated that 2.3% of individuals will score 70 or below (2 standard deviations [sD]), and 6.7% will score 77.5 or below (1.5 SD) on global intelligence tests. These are cutoff points at which intervention and special education have typically been provided.27 Any factors in a population that result in a 4-point decrease in IQ, as was found with the heavy current marijuana users, would increase to 5.5% the proportion of individuals with an IQ of 70 or below and to 11.0% those with an IQ of 77.5 or below. A corresponding decrease in proportions would be expected on the other end of the distribution (people with higher IQ scores). For comparison, an IQ decrement of 5 points has been observed in children exposed prenatally to 3 alcoholic drinks per day,28 of 3.75 points in offspring exposed prenatally to cocaine 27 and of 2.6 points after low lead exposure.29


The IQ deficit among heavy current users in the present study likely reflected residue of the drug in their bodies.10 Assuming use of at least 5 joints per week by subjects in this group and given the elimination half-life of THC in the plasma of long-term marijuana users,30,31 such quantities and patterns of smoking are likely to result in an accumulation of THC in the body.


Although the heavy current users experienced a decrease in IQ score, their scores were still above average at the young adult assessment (mean 105.1). If we had not assessed preteen IQ, these subjects would have appeared to be functioning normally. Only with knowledge of the change in IQ score does the negative impact of current heavy use become apparent.


There were no differences in IQ score at the preteen assessment among the future groups of users and the future non-users. This finding suggests that, at least in a low-risk, white, predominantly middle-class sample, IQ score before any marijuana use is not a predictor of future marijuana use.


We investigated the possibility of a longer-lasting deficit, perhaps representing a neurotoxic consequence on the central nervous system (CNS), using data for the former users. The mean IQ difference score for the former users did not differ significantly from that for the non-users, which suggests a lack of long-term effects. Similarly, there was no negative impact on IQ difference among former heavy users relative to non-users (in contrast to the situation for current heavy users). This lack of a long-lasting negative impact suggests the absence of any CNS alteration as reflected by global IQ performance.


Both the negative effects of use of at least 5 joints weekly and the lack of long-term effects found in this study should be interpreted cautiously. The relatively small number of subjects for whom data were available, the length of time that the drug was used, the estimated total number of joints smoked and the young age of the subjects may serve, individually or collectively, to moderate effects. Smoking at least 5 joints weekly should not be interpreted as a definitive threshold, as subjects were at low risk for other factors that could have a negative synergistic effect on IQ score. It is also important to emphasize that broad intellectual functioning may be less vulnerable to the consequences of marijuana use than more specific cognitive domains, such as attention and memory.7,13,14


The popularity of marijuana among youth has been increasing during the past 4 years,32,33 and pressure on governmental agencies to assess the medical uses of the drug and to reassess the legal status of the drug has been growing.34 These trends emphasize the need to continue investigating the cognitive consequences of both current and previous marijuana use.



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