The Surprising Effect Of Marijuana On Morphine Dependence

[grace]

Injections of THC, the active principle of cannabis, eliminate dependence on opiates (morphine, heroin) in rats deprived of their mothers at birth. This has been shown by a study carried out by Valérie Daugé and her team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / INSERM) in the journal Neuropsychopharmacology. The findings could lead to therapeutic alternatives to existing substitution treatments.

 

In order to study psychiatric disorders, neurobiologists use animal models, especially maternal deprivation models. Depriving rats of their mothers for several hours a day after their birth leads to a lack of care and to early stress. The lack of care, which takes place during a period of intense neuronal development, is liable to cause lasting brain dysfunction. Valérie Daugé's team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / Inserm) analyzed the effects of maternal deprivation combined with injections of tetrahydrocannabinol, or THC, the main active principle in cannabis, on behavior with regard to opiates.

 

Previously, Daugé and her colleagues had shown that rats deprived of their mothers at birth become hypersensitive to the rewarding effect of morphine and heroin (substances belonging to the opiate family), and rapidly become dependent . In addition, there is a correlation between such behavioral disturbances linked to dependence, and hypoactivity of the enkephalinergic system, the endogenous opioid system.

 

To these rats, placed under stress from birth, the researchers intermittently administered increasingly high doses of THC (5 or 10 mg/kg) during the period corresponding to their adolescence (between 35 and 48 days after birth). By measuring their consumption of morphine in adulthood, they observed that, unlike results previously obtained, the rats no longer developed typical morphine-dependent behavior. Moreover, biochemical and molecular biological data corroborate these findings. In the striatum, a region of the brain involved in drug dependence, the production of endogenous enkephalins was restored under THC, whereas it diminished in rats stressed from birth which had not received THC.

 

Such animal models are validated for understanding the neurobiological and behavioral effects of postnatal conditions in humans. In this context, the findings point to the development of new treatments that could relieve withdrawal effects and suppress drug dependence.

 

The enkephalinergic system produces endogenous enkephalins, which are neurotransmitters that bind to the same receptors as opiates and inhibit pain messages to the brain.

 

Date: 6 July 2009

Source: Red Orbit News

http://www.redorbit.com/news/health/171606...ine_dependence/

[Crunchy]

very interesting

another weapon to put in my arsenal against anti-pot people.

[luciddreaming]

So, in other words, it's an ANTI-gateway drug! HAHA

This really is awesome.

[420 HELI]

Thanx grace

[Ozzy420]

I know way back when i was hooked on heroin over 10 years back now, when times were tough when i dident have the $$ to score it or it was hard to find if i smoked a shit load of weed it would take a big part of the edge off the hell i would go through drying out so i have a good idea what they are talkin about, but it would be interesting to see what THC is like to inject but i dout i would try it that way as it bring back to much of what i gave up...

[Radic]

avedic medicine from india recomends treating drug addiction with cannabis

same in the many tradicinal cannabis producing countries like morroco, lebanon and the middle east

even china had these problems and found the cure in cannabis

your so right dreamer

anti gateway

truth is and allways was

cannabis is the gate way to freedom from drug addiction

 

forward ever

free cannabis

heal the people

heal the land

[luciddreaming]

ozzy - Apparently it is pretty shit to inject THC alone. THC and CBD is good but just THC just makes you feel like shit and you get paranoid and depressed.

[jabez]

ozzy - Apparently it is pretty shit to inject THC alone. THC and CBD is good but just THC just makes you feel like shit and you get paranoid and depressed.

 

Where did you hear that?