I know you asked Merl1n, but I'll drop my 2cents as well Itchy. Codeine is generally the wrong choice for tooth related pain. Most (pre extraction) tooth pain is related to infection and inflammation. There isn't much space for swelling in the gum so inflammation in this area puts a lot of pressure on nerve endings and can hurt really bad. An anti-inflammatory drug, like nurofen (and backed up by an antibiotic to clear the infection), is much more likely to bring relief to that sort of pain than codeine. Codeine would be good for after extraction because then you are dealing with tissue trauma. The last time I had an abscessed tooth, I was searching for something to kill the pain as I ran out of nurofen... my regular Targin (oxycodone/nalaxone) didn't touch it, liquid morphine didn't touch it. I spent a night with half my face in agony, alternating hot and cold compresses to my face and gargling with Peter Mac anaesthetic mouth jelly. Got the pain back to bearable once I got to the shop for an inti-inflammatory and then to the gp for an antibiotic. All of the opioid/opiate drugs can cause delirium (particularly in older individuals), but I have never heard of CBD increasing the likelihood of delirium. Codeine is well known for causing bizarre dreams, especially in higher than 10mg doses. Corticosteroids are another group strongly associated with psychoactive side effects. I get really nasty nightmares (that don't fade on waking, the sort of thing that leaves me traumatised all day) when I take prednisolone. The way I get around that is cannabis. If I have to take a corticosteroid, I also have small nightly doses of canna oil. Canna oil effectively blots out the dreams and means I can get some sleep. So yeah, seems strange to me that a dr is saying that CBD is interacting with the codeine to produce delirium. I hope your family member is feeling better now.