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The endocannabinoid system


boydey

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One place we find cannabinoids very similar to those that marijuana produces is in our bodies. Most animals including humans and other vertebrates produce their own cannabinoids. These endogenous cannabinoids regulate nerve and immune function and many other critical metabolic processes. This is done in part through a unique process called retrograde signaling. The body's endogenous cannabinoids regulate the nerves signaling output. In the early 1990s scientists identified a natural human cannabinoid. It was named anandamide from the Sanskrit word for bliss and is chemically described as n-arachidonoylethanolamide AEA. Since then four other endogenous cannabinoids have been identified. 2-arachidonoylglycerol 2-ag .2-arachidonoylglyceryl ether noladin ether .n-arachidonoyl dopamine nada.and virodhamine oae. There are two primary receptors that absorb cannabinoids known as cb1 found mostly in parts of the brain and cb2 which is distributed throughout the body but is concentrated in the organs and the gut. The location of those receptors which have as much affinity for plant cannabinoids as the body's own has revealed much about how marijuana effects us. Three other probable endocannabinoid receptors have been identified gpr55. Gpr119 end gpr18 and possible sixth LIP has affinity for gpr55 receptor. The location of the cannabinoid receptor indicates why it is impossible to fatally overdose on marijuana no how hard you try. Alcohol and drugs derived from the poppy plant attach to receptors in the brainstem which controls your lungs and heart. These central nervous system depressants slow breathing and heartbeat and with overdoses can stop both. In contrast there are no cannabinoid receptors in that part of the brain. Taking a big hit increases your heart rate and affects your blood pressure but in a more complicated way perhaps tied to the dilation of blood vessels which also contributes to that most telltale sign that someones been toking bloodshot eyes. But government sells drugs that kill hundreds a year tobacco alcohol opium base drugs so legalise cannabis now

 

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