New Drug Dims Pain Like Pot

[Dragonfan]

The West Australian

 

24 November 2008

 

Scientists have found a way to release the pain-relieving potential of one of the same proteins in the body activated by marijuana, according to a study released on Sunday.

 

In experiments on mice, researchers found a chemical that prevents a naturally occurring enzyme from blocking this cannabinoid receptor, called 2-arachidonoylgylcerol, or 2-AG.

 

Once the enzyme, known as MAGL, is deactivated, the protein is more effective in dampening pain, say the team, led by Benjamin Cravatt of the Scripps Research Institute in La Jolla, California.

 

The complex human cannabinoid system is thought to hold great potential for the control of chronic pain, and could also prove useful in the treatment of anxiety, depression and even obesity.

 

In earlier research, Cravatt and colleagues decoded the chain of chemical reactions that acted on another cannabinoid receptor, AEA, paving the way for the development of pain-relieving medications.

 

But finding the key for unlocking 2-AG proved more difficult. The tools - selective and efficacious MAGL inhibitors - just weren't there, said Jonathan Long, a graduate student at Scripps and lead author of the study.

 

The breakthrough came thanks to a new technique for rapidly testing large numbers of chemical compounds - all potential inhibitors - called Activity-Based Protein Profiling.

 

One of the 200 compounds researchers created was particularly effective in blocking MAGL, and did not appear to interfere with any of several dozen other brain enzymes.

 

Tests on mice showed the new molecule - JLZ184 - increased the concentration of 2-AG in the brain, significantly reducing pain in the lab animals.

 

The molecule did, however, have at least two drawbacks, highlighted by the complex web of reactions in neurochemical pathways: JLZ184 caused hypothermia, a lowering of the body temperature; and reduced movement.

 

These side-effects would have to be managed in any treatments developed for humans, the researchers said.

 

AFP

[brick]

The molecule did, however, have at least two drawbacks, highlighted by the complex web of reactions in neurochemical pathways: JLZ184 caused hypothermia, a lowering of the body temperature; and reduced movement

 

 

 

Would it not be easier to legalize cannabis. Then there would be no side effects. This is one plant, they seem not to be able to get their science around. Would save millions to just admit they can't figure it out and say "Ok lets make it legal".

[marrywanna]

Would it not be easier to legalize cannabis. Then there would be no side effects. This is one plant, they seem not to be able to get their science around. Would save millions to just admit they can't figure it out and say "Ok lets make it legal".

agreed tenfold...

 

doesnt australia have enough ppl smoking to make it legal anyway??

[ashka]

So true, just legalize cannabis and get to the real issue of helping suffering people instead of waiting for science to get up to date with such a wonderfully complex plant.