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Neuroprotective antioxidants from marijuana

Guest Urbanhog

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:D Most interesting, but does this antioxidant effect occur in the human brain? And would the effects of THC and CBD as antioxidants be mitigated or enhanced according to method of intake? Smoking might get it there quicker, but would the smoking effect itself nullify any potential benifits? :P Just a few thoughts....


Well done tom, so long as people like you bring this kind of research to the attention of the people, we may have hope yet....

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Neuroprotective antioxidants from marijuana.


Hampson AJ, Grimaldi M, Lolic M, Wink D, Rosenthal R, Axelrod J.


Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892, USA. aidan@codon.nih.gov


Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.


Publication Types:


Review, Tutorial


PMID: 10863546 [PubMed - indexed for MEDLINE]


LMAO. I did not understand a single word of this article, and don't believe in antioxidants anyway. Just an opinion based on ignorance, don't try to debate it with me :D

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