Why Havent I Heard of These Guys before?

[Ruen]

I just came accross in my research an interesting company in the UK called GW Pharmaceuticals they have a product which has been approved for use by Health Cannada as of April 2005 for use on patients with 'central neuropathic pain'

 

the product is what they call a "Oromucosal Spray" which i am assuming is a puffer that uses a liquid not a powder as i believe is the case with asthma. the product contains THC and CBD in a ratio of one to one. so far that is all the information i have found i forwarded an email to the company asking them to send me information on the product.

 

the product has many other uses that it is currently going through approval for.

 

 

This Same company is trying to create a replacement for the methadone program using a drug called Diamorphine which is meant to be a safer alternative.

[Ruen]

This Is the Information they provide on Cannabinoids

 

 

 

 

 

 

Naturally occurring cannabis (Cannabis sativa) contains a group of chemical compounds not found in other plants known as cannabinoids. Over 60 different cannabinoids have so far been identified but the role and importance of many of these has yet to be fully understood. Identified cannabinoids include Delta-9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN), Cannabichromene (CBC) and Cannabigerol (CBG).

 

Of these only two cannabinoids have been well characterized - delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

 

THC is the most prominent cannabinoid since it is the principal psychoactive agent. There is an abundance of literature in the public domain on the pharmacology and toxicology of synthetic THC. By contrast, CBD is not psychoactive.

 

Both THC and CBD have important pharmacology: THC has analgesic, anti-spasmodic, anti-tremor, anti-inflammatory, appetite stimulant and anti-emetic properties, whilst CBD has anti-inflammatory, anti-convulsant, anti-psychotic, anti-oxidant, neuroprotective and immunomodulatory effects. CBD is not intoxicating and indeed it has been postulated that the presence of CBD in cannabis may alleviate some of the potentially unwanted side-effects of THC. There is currently limited scientific information on the pharmacology and toxicology of the other cannabinoids. Cannabinoids are believed to be effective in suppressing muscle spasticity, spasms, bladder dysfunction and pain symptoms of MS .

 

GW believes that the beneficial therapeutic effects of cannabis based medicines result from the interaction of different cannabinoids, hence GW's medicines consist of cannabinoids in different ratios. To date GW's research has primarily focused on the two principal cannabinoids THC and CBD. In addition GW believes that other components within the plant are also important which is why GW's medicines are made from botanical extracts.

 

Phytocannabinoids, Endocannabinoids and Synthetic Cannabinoids

The term "cannabinoid" has different meanings. Cannabinoids were originally defined as a group of C21 compounds uniquely produced by the cannabis plant. Subsequent development of synthetic cannabinoids and the discovery of natural cannabinoids in the body (“endocannabinoids”) has somewhat blurred this definition. The molecules derived from the plant itself are therefore now termed “phytocannabinoids”. Synthetic cannabinoids are those which have been man-made.

 

The Cannabinoid Receptor System

Only in the last decade or so, a natural cannabinoid receptor system has been discovered in the human body. It is by interacting with these receptors that cannabinoids exert many of their pharmacological effects. The discovery of the cannabinoid receptor system has sparked renewed interest in the therapeutic potential of cannabinoids by providing important new targets for drugs. There are at least two types of cannabinoid receptors in mammalian tissues, CB1 and CB2. CB1 receptors are present in the brain and spinal cord and in certain peripheral tissues. CB2 receptors are expressed primarily in immune tissues. There is preliminary evidence to suggest that additional cannabinoid receptor types may exist.

 

CB1 receptors are widely distributed but are particularly abundant in some areas of the brain including those concerned with movement and postural control, pain and sensory perception, memory, cognition, emotion, autonomic and endocrine functions. The role of the second type of receptor, CB2 receptor, is still under investigation but it is believed to mediate the immunological effects of cannabinoids.

The cannabinoid system interacts with many other neurotransmitter/neuromodulator systems such that cannabinoids affect almost every body system.

[Jess Stone]

Well the product is actually called Sativex® and you spray it under your tongue to get drugged from it ,I suppose you could spray it on the inside of your mouth inside your cheeks and at a guess spray it up the nostrils. I wonder if it would work sprayed up you rear end or tip of dick or up fanny as all of these places have mucous membranes as well. Now if it works on all mucous membranes 69'ers might be VERY special.

 

Diamorphine is just another name for HEROIN which is a brand name for diacetylmorphine hydrochloride or Diamorphine by BAYER Pharmaceuticals of Germany which I believe may be prescribed in the UK for addicts (sometimes/used to be) and Terminal cancer/other fatal terminal diseases.

 

[Ruen]

yeah as i said safer then methadone then but i didnt realise it was heroin

[Jess Stone]

Its a funny world ,another opium poppy drug is called Thebaine it produces stimulatory, with strychnine-like convulsions, rather than depressant effects !! But it gets weirder Naltrexone the stop junkies in there tracks drug is made from Thebaine so the opiate blocker drug that stops addicts getting a high is made from opium !!!

 

Did you know that 50% of the worlds LEGAL Morphine comes from opium poppies grown in TASMANIA ?